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98 In COPD patients, macrophages release large amounts of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) in the airways of COPD patients due to long-term exposure to tobacco smoke and other harmful substances

The shoulder blade provides the stable base from which the rotator cuff operates