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Substantiation of the hypothesis of BT as a mechanism of sepsis in humans is difficult to demonstrate once trauma or burns have occurred, or when patients are septic, have disrupted circulation to the intestine, or have a damaged intestinal epithelial surface itself

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Diagnosis typically involves a patient reporting urinary symptoms to their general practitioner (GP), who may conduct a prostate examination and order tests like PSA (prostate-specific antigen) blood test to rule out prostate cancer