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Description

Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high-risk groups are provided in the full prescribing information [see Dosage and Administration (2.1 and 2.4), Contraindications (4), Warnings and Precautions (5.1), Drug Interactions (7), and Use in Specific Populations (8.6, 8.7)]

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Although this conceptual framework is promising, further longitudinal and mechanistic research is needed to determine whether low HRV directly contributes to the development of inflammaging or merely serves as a downstream indicator

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