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Recent large cohort studies established that, within normal range, low serum PRL is associated with metabolic syndrome and obesity in children ( In concordance with epidemiologic studies, circulating levels of PRL are reduced in the ob/ob and db/db obese and diabetes mouse models, and in streptozocin-induced (STZ) T2DM rats

Environ Health Perspect 108:6771 Zamwar UM, Muneshwar KN (2023) Epidemiology, types, causes, clinical presentation, diagnosis, and treatment of hypothyroidism

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Wegovy in 2021), meaning there isnt a lot of long-term safety data available