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Given that impaired autophagy and dysregulated mucin secretion are key contributors to barrier dysfunction, TB-500s regenerative and anti-inflammatory actions may indirectly support mucin2 production and mucus layer integrity, though direct evidence in colitis models remains limited

It means the risk profile differs depending on the route, dose, and individual factors

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Nutrients to specifically ask about: Vitamin B12: Reduced food intake, especially in patients previously on metformin (which independently impairs B12 absorption), increases deficiency risk