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The biological heterogeneity of both ASD and SSD, echoing similar findings for other neurodevelopmental disorders such as ID and ADHD, therefore raises the question whether this heterogeneity is reduced in subsets of individuals with a specific neuropsychiatric diagnosis who share a common genetic basis

It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

There is no completed human weight-loss trial of 5-Amino-1MQ, so the effect in people remains unproven despite heavy marketing

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