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HbA1c: Hemoglobin A1C Introduction There are many definitions of metabolic syndrome (MetS) but most of them include three of five cardiovascular disease (CVD) risk factors: hypertriglyceridemia, low levels of high density lipoprotein-cholesterol (HDL-C), abdominal obesity, hypertension, and hyperglycemia (Murthy et al., 2016[37])

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This window is sufficient to observe early changes in body composition and GH axis responsiveness

A more comprehensive evaluation of the same cohort using spatial transcriptomics revealed more detailed vascular and immunological features of microvessels in the brain, including serum protein extravasation, platelet accumulation and coagulation system activation 22