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These are two separate, independently documented mechanisms that are each plausibly relevant to rosacea

18 Continued efficacy was confirmed in a similar study in which Psoriasis Area and Severity Index (PASI) score improvements of at least 50%, 75%, and 90% was shown to be achieved by increasing percentages of participants over a period of years

Choose Safety Profile Adverse reactions reported in 3% of Wegovy 2.4 mg injection-treated adolescent patients aged 12 years and older with obesity and more frequently than with placebo 1 Gastrointestinal disorders were the most frequent adverse events with Wegovy ( 62% vs 42% with placebo) 2.3% of patients treated with Wegovy vs 1.5% of patients who received placebo discontinued treatment as a result of gastrointestinal adverse events 6 Mean increases in resting heart rate of 1.2 beats per minute from baseline were observed with patients taking Wegovy vs a decrease of 2.3 beats per minute with placebo 6 Adverse reactions with Wegovy treatment in pediatric patients aged 12 years and older were similar to those reported in adults

This is also linked to the production of trimethylamine-N-oxide, which in turn leads to an increased risk of atherosclerosis