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If a multivitamin lists 5 g on the label but actually contains 17% less, it would result in only 8.3 g absorbed per week instead of the 8.4 g that the RDA is based on, but this amount would still cover most peoples needs

As one review paper notes, even the governmental agencies responsible for defining dietary recommendations acknowledge that the benefits of micronutrient consumption may continue on a continuum well above the RDA

A few possible side effects of Neurobion include: Diarrhea Constipation Nausea and vomiting Abdominal cramps Headache Malaise (general feeling of discomfort) Dizziness Dyspnea (shortness of breath) Blurred vision Chest pain Itching Skin rash A feeling of swelling in the entire body Eczema Dry mouth Excessive thirst Flushing (redness in the face or neck because of a sudden increase in blood flow) Shivering Cyanosis (bluish discoloration of the skin caused by the lack of oxygen) Excessive urination Allergic reactions in rare cases Rash Difficulty breathing Swelling in the face or mouth Although these side effects are possible, they are not commonly experienced, so it is considered safe to take these supplements

The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A