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Cancer cells greed for glucose inactivates effector T cells and DCs, whereas programmed cell death ligand-1 (PD-L1) expressed by tumor cells stimulates glycolysis and the Akt pathway in cancer cells, thereby helping maintain its proliferation (Jayavelu et al., 2022)

Nanocarriers such as liposomes, dendrimers, polymer nanoparticles, and micelles can deliver chemotherapeutic agents directly to cancer cells, minimizing damage to healthy tissue and improving drug bioavailability (168)