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Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC, Look AHEAD Research Group
longum isolates) or synbiotic formulations can reduce diet-induced hepatic lipid accumulation, lower serum ALT/AST and systemic inflammatory markers, and restore gut barrier integrity effects that are mechanistically linked to increased SCFA and ILA production, activation of AMPK/PPAR-dependent hepatic lipid oxidation pathways, and favourable remodelling of bile-acid pools (FXR/TGR5 signalling) (100102)