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However, it's not without its drawbacks, including slower motility and an increased risk of SIBO and other digestive complications

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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

After 10 years of treatment, the incidence of MALE was significantly lower in the GLP-1RAs group than in the non-GLP-1RAs group ( 6.2 Liver fibrosis/Cirrhosis The progression of fibrosis generally stems from the activation of pro-fibrogenic immune cells, such as M2 cells, which follow inflammatory immune cells that cause injury