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Nat Med (2012) 18(12):184756

This vascular dysfunction may cause the development of cerebral amyloid angiopathy and may contribute to the neurodegenerative processes observed in AD [17]

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Pharmacodynamics: During the MAD phase, after subjects received once-weekly administration of HS-20094 via subcutaneous injection for four consecutive doses, AUC0-2h glucose on day 22 of HS-20094 group was lower than that in placebo group, and there was no significant difference between the two groups in AUC0-2h insulin on day 22