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Data from a recent study in older HIV-infected patients presented at the 19th AIDS Conference (28) did not find any changes in expression or activity of carnitine palmitoyl transferase 1 but decreased activity of hydoxyacyl coenzyme A dehydrogenase, which suggests that mitochondrial entry of NEFAs is not impaired in these patients and that the defects could lie in impaired mitochondrial -oxidation

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