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J Clin Med 6(9):86 Mueller DM, Allenspach M, Othman A et al (2015) Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

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8 The GlyNAC combination (glycine + NAC, addressing both rate-limiting precursors simultaneously) produced particularly robust results in a 16-week, placebo-controlled RCT in older adults: it corrected glutathione deficiency, reduced oxidative stress, improved mitochondrial fatty-acid oxidation, and enhanced physical performance measures including gait speed and the 6-minute walk test

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