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10 mg vial + 2 mL BAC water: Concentration = 5 mg/mL 1.75 mg dose = 35 units (0.35 mL) on a 100-unit insulin syringe 2 mg dose = 40 units (0.40 mL) on a 100-unit insulin syringe Doses per vial: ~5 doses at 2 mg, or ~5 doses at 1.75 mg Supplies Needed 12 vials PT-141 (10 mg each) provides 510 doses per vial at standard dosing 1 vial bacteriostatic water (30 mL) Insulin syringes (2931 gauge, 100-unit) Alcohol prep pads Administration Injection Technique PT-141 is administered via subcutaneous (SubQ) injection

Serious side effects are possible, including liver injury, increased risk for opioid withdrawal, and life threatening opioid intoxication

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doi: 10.1007/s00210-023-02921-8 45 HuFLinC