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For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

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The dominant categories are cell-culture studies in dermal fibroblasts and keratinocytes (collagen biochemistry, gene-expression observations, signal-transduction effects), copper-chemistry studies (chelation stability, antioxidant chemistry), and small-animal wound-repair models

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