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Because PUFA moieties are more susceptible to lipid peroxidation than monounsaturated fatty acyl (MUFAs) moieties, the proteins involved in the incorporation of PUFAs into membrane lipids, such as Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) and Lysophosphatidylcholine Acyltransferase 3 (LPCAT3), are pro-ferroptotic enzymes, while proteins involved in the incorporation of MUFAs into the membrane, such as Acyl-CoA Synthetase Long-Chain Family Member 3 (ACSL3), are anti-ferroptotic [1215]

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Heil and Kottilil, 2022)