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The absence of MZB-mediated immunity was substantiated by the lack of anti-TNP IgM at 7 days post-immunization with TNP-Ficoll in Gclc fl/fl Mb1-Cre + mice (Supplementary Fig

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This binding activates c-Met phosphorylation, which turns on the HGF receptor and triggers a series of signalling events

Indeed, insulin-stimulated phosphorylation of multiple TBC1D4 phosphosites was impaired in insulin-resistant muscle from diabetic or TNF-infused patients [99,100], and conversely, exercise-induced phosphorylation of TBC1D4 S711 was required for improved insulin action in mice [101,102]