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On the platform side, Roche is using NVIDIA BioNeMo , which is optimized for biological sequence data and molecule generation

As noted above, the Yoon et al

Certain nuclear receptor agonists, including constitutive androstane receptor (CAR), pregnane X receptor (PXR) and peroxisome proliferatoractivated receptor (PPAR), contribute to hepatocyte growth and proliferation by promoting the nuclear translocation of YAP

The one or more hepatocyte growth factor mimics has or have a general structural formula R] -R 2 -R 3 -NH-(CH 2 ) n -C-IS[H2 1 2 3 where Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine