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In this pathophysiological context, de novo lipogenesis is thought to contribute to the origin of NAFLD, which is often associated with insulin resistance [78,170]

In a dedicated food-effect study published in Clinical Pharmacology and Therapeutics in 2024, orforglipron absorption was evaluated under fasting conditions and following a high-fat, high-calorie meal (the standard FDA food-effect test meal containing approximately 50% of calories from fat and 800-1000 total calories)

The metabolically active adipose tissue surrounding the liver and abdominal organs

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