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Although evidence from clinical trials has shown GLP-1 RAs to be safe and efficacious in people living with T2DM and renal impairment, their use is uncommon in this patient population

Answer: GLP-1 medications such as semaglutide and tirzepatide act on the GLP-1 pathway, while cagrilintide acts on the separate amylin pathway, which is why the two are additive rather than redundant when used together

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