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Cancer 1991;68:324330

Common skin-related symptoms: Dry, rough, or flaky skin Thickened skin with reduced elasticity (can worsen flare-ups) Slower recovery from eczema outbreaks Increased cold sensitivity, which often makes dryness worse Hyperthyroidism (Overactive Thyroid) Too much thyroid hormone speeds things upincluding your metabolism and your skins oil and sweat production

High blood sugar, possibly extreme and associated with diabetic acidosis, coma, or death, has also been reported in patients treated with Seroquel

Simultaneously, ROS disrupts insulin signaling in peripheral tissues by promoting IRS-1 serine phosphorylation and degrading phosphatidylinositol-3-kinase (PI3K)/Akt activation, leading to insulin resistance (Papaetis et al., 2025)