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2.4 Integration of gut, brain, and kidney signals The gut-brain-kidney axis is closely linked to the development and progression of several specific diseases, with each organ system influencing the others in ways that can exacerbate or mitigate these conditions, including CKD (Figure 2), hypertension, irritable bowel syndrome, and kidney stones

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Endothelial NOS-derived NO induces the dilation of all types of blood vessels by both S -nitrosylation of proteins and through the stimulation of soluble guanylate cyclase (sGC) and increasing cGMP production in smooth muscle cells