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SURPASS J-combo study comparing people with T2DM in a Japanese population with a high HbA1c on oral antihyperglycemic monotherapy on 5, 10, or 15 mg of once weekly tirzepatide for 52 weeks showed an improvement of glycemic and lipid control, weight loss and reduction in blood pressure [57]
Placement of real transdermal drugs makes a difference, but for GLP-1 patches sold online, putting them in certain spots does not make them work better
Localized skin reactions are relatively common, affecting roughly 1 in 6 patients in some studies
Finally, source quality is everything: Contaminated peptides from gray-market suppliers are the real danger peptide users should be worried about (especially if the user improperly reconstitutes and doses them due to human error)
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