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In its invasive hyphal form, Candida penetrates the intestinal epithelium and releases more than 70 identified mycotoxins including acetaldehyde, gliotoxin, and candidalysin that trigger systemic inflammation, impair mitochondrial function, disrupt neurotransmitter synthesis, and compromise the integrity of the gut barrier, producing a multi-system clinical presentation that spans gastrointestinal, neurological, endocrine, dermatological, and immunological domains
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The administration of leptin into aP2SREBP-1c transgenic mice from the Brown and Goldstein laboratory resulted in dramatic benefits in glycemic parameters, insulin action, and hepatic steatosis, which could not be explained by its effect on food intake alone, providing the premise to undertake leptin replacement in human patients (188)