Sci Signal 2:ra45 Mittler R, Zilinskas BA (1991) Purification and characterization of pea cytosolic ascorbate peroxidase
This modification inhibits its phosphorylation and deactivates the AMPK pathway, resulting in diminished matrix synthesis, increased degradation, reduced autophagy, and accelerated cellular senescence
4.4.4.5 Biomarker integration for disease staging and intervention monitoring The metabolite panel encompassing IS, pCS, PAGln, circulating BCAAs, and homocysteine provides a comprehensive readout of gut-liver-kidney axis dysregulation
( Reference Norlund, Grubb and Fex 29 ) demonstrated a significant correlation between plasma Hcy and serum creatine, and suggested that creatine turnover may be a factor determining Hcy levels