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Simultaneously, the upregulation of co-stimulatory molecules (CD80/86) of dendritic cells conditioned in the irradiated gut mucosa suggests a pro-inflammatory antigen-presenting phenotype

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Li et al., 2018), where it exerts its neuroprotective effects primarily by inhibiting the expression of pro-apoptotic factors such as Bax, caspase-3, and caspase-12, while promoting the expression of anti-apoptotic factors Bcl-2 and Bcl-xL

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doi: 10.2337/diabetes.53.2007.S119

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