Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, et al
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These Authors failed to evidence significant changes in indexes of insulin resistance and speculated that other classical effects of GLP-1 RA, such as suppressed glucagon secretion, with consequent reduced hepatic glucose production, could have been involved in the improvement in glucose metabolism and ectopic fat deposition [54]
On the other hand, those in the placebo clinical trial group only showed average weight reductions of 3% [3]
