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IL-1 has been consistently shown to be associated with neurogenesis in brain, especially in the hippocampal region.4950 It is of note that the inhibition of IL-1 blocks the decrease in neurogenesis caused by acute stress, as well as the anhedonic and antineurogenic effects of chronic stress.49 A previous study revealed that sustained hippocampal IL-1 expression has a detrimental effect on adult neurogenesis.51 IL-1 is also known to be involved in the IFN--induced suppression of neurogenesis.52 Leukemia inhibitory factor (LIF) is also an important cytokine involved in schizophrenia

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