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In addition to the inherent challenges associated with these agents, Gln metabolism lacks tumor specificity and involves multiple metabolic pathways within cells, which can lead to false positives in areas of high metabolic activity

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Notably, about one in four of these patients did not carry a type 2 diabetes diagnosis , suggesting that a substantial portion of GLP-1 use is being driven by weight loss and other emerging indications outside of diabetes care (Figure 2)

They may suggest rest, using ice or heat, or taking anti-inflammatory medications