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3.7 GRADE assessment In the GRADE assessment, the HR effects for nonfatal stroke and UA hospitalization were downgraded to moderate due to imprecision [no statistically significant results and total event counts below the optimal information size (OIS) threshold]

Neuroprotection by melatonin against ischemic neuronal injury associated with modulation of DNA damage and repair in the rat following a transient cerebral ischemia

[1] [2] According to NICE guideline NG28 (Type 2 diabetes in adults: management), GLP-1 receptor agonists may be considered when metformin is contraindicated or not tolerated, or when other treatments have not achieved adequate glycaemic control, particularly in patients with a BMI 35 kg/m (or lower in certain ethnic groups) or when weight loss would provide additional clinical benefit

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