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External hemorrhoids may also cause intermittent swelling, irritation, and mild discomfort, especially after a period of diarrhea or constipation

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Surgical interventions typically produce greater and more durable weight loss than pharmacotherapy alone and may be more appropriate than escalating to combination drug regimens with uncertain safety profiles

Managing Side Effects During the First Few Weeks As these medications slow digestion, it's common to experience temporary side effects at the beginning, including: Nausea Heartburn Constipation Feeling overly full Fortunately, these symptoms are usually manageable