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FOXO4-DRI has been investigated extensively in preclinical academic literature for p53 transactivation domain binding, senescence-associated apoptosis pathway research, p16 and IL-6 marker dynamics in senescent cell research models, and SASP (senescence-associated secretory phenotype) signaling

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Heterogeneity was assessed using the I statistic, where values above 50% were interpreted as indicating moderate to high heterogeneity, alongside Cochranes Q test to evaluate the statistical significance of between-study variation

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