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Inflammatory metabolic pathways such as PI3K-Akt have been longitudinally associated with bone mineral density in adolescents, indicating that their pharmacological modulation may interfere with critical periods of bone formation

Moreover, if patients are suffering from side effects such as vomiting or diarrhoea (common side effects during the earlier days of injecting), this can certainly reduce the effectiveness of the pill, raising the risk of unintended pregnancy

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