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Institutions like the Open Medicine Foundation have actively investigated how bypassing this broken pathway with direct methylcobalamin supplementation can help restore methylation function, reduce debilitating fatigue, and improve cognitive clarity in ME/CFS patients

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The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity

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As an ointment, its been used to treat psoriasis for years

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