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Loss of protective effects: Cardiovascular and kidney protective benefits likely diminish

The tradeoff is clear: retatrutide has the best weight loss data but also the most uncertainty: no FDA approval, no standardized commercial product, and reliance on research peptide or compounded sources

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Other nonpharmacologic approaches to HFpEF management include stimulation-based technologies, nerve ablation therapy and mechanical circulatory support devices, though their utility is less clear and further research into their efficacy is warranted