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147 Whereas phosphatidylinositol 4,5-bisphosphate (PIP2) localizes to the apical membrane, phosphatidylinositol 3,4,5-trisphosphate (PIP3) is enriched at the basolateral membrane 6,148 (Figure 3(a))

6 Approved to reduce the risk of major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease