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Accordingly, many lines of evidence indicate that Nrf2 overactivity is implicated in chemoresistance to different conventional drugs including cisplatin [78], 5-fluorouracil [79], doxorubicin [80], vincristine [81], etoposide [82] and mitoxantrone [83]

Daily for 12 to 16 weeks, then twice per week for maintenance

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About the Study Trial measured effect of glutathione supplementation at 250 mg/day and 1000 mg/day on glutathione levels in different blood components and exfoliated buccal mucosal cells over a six month period