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When treating millions of people with medications like semaglutide, even relatively rare side effects will occur in a largenumber of people Starting low and going slow is important to minimize side effects. Susan Yanovski, MD, National Institute of Diabetes and Digestive and Kidney Diseases Common Side Effects and What Helps When To Call a Doctor

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However, this effect varies individually and has not been definitively established in clinical trials, so patients should monitor their own symptom patterns and discuss timing adjustments with their healthcare provider