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Aqueous preparations of Rhodiola rosea have shown metabolic benefits by reducing blood glucose levels in streptozotocin-treated diabetic rats, an effect that is negated upon adrenal gland removal

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Niacinamides multimechanistic action (melanogenesis inhibition, melanosome transfer blockade, anti-inflammatory effects) makes it an ideal combination partner with tyrosinase inhibitors and anti-angiogenic agents