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Overall, the extent to which GLP-1RAs cross the bloodbrain barrier remains uncertain in pre-clinical studies 4 , and further discrepancies are expected in translating these data from animals to humans

This understanding is in line with the chronotropic effects of GLP-1 RA treatment, which in a large meta-analysis was shown to be associated with heart rate increases of up to 3.35 beats/min (Sun et al., 2015)

PT-141 Side Effects: What Patients Should Know Like any prescription therapy, PT-141 carries the potential for side effects