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Under normal physiological conditions, GLP-1 receptors (GLP-1R) are expressed on the dendritic terminals of vagal afferents innervating the gastrointestinal tract [8], in diencephalic brain regions involved in homoeostatic and metabolic control of feeding such as the lateral hypothalamus, and the nucleus arcuatus, and also in other brain regions that specifically regulate reward processing and motivated behaviour such as the ventral tegmental area (VTA) and the nucleus accumbens (NAc) [9]