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Statistical analysis The results are depicted as the mean SEM

PMCID: PMC9927842 Onyeakazi UM, Columb MO, Rosalind A, Kanakarajan S, Galley HF (2024) Melatonin treatment has consistent but transient beneficial effects on sleep measures and pain in patients with severe chronic pain: the DREAM-CP randomised controlled trial

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An anti-MITF small interfering RNA conjugated to a skin-penetrating peptide in a cream formulation was also successfully used for the treatment of patients with melasma, with an almost complete restoration of skin color on facial lesions after 12 weeks [110], but these agents need optimized topical delivery systems [111]