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The PerR transcription factor is triggered not by oxidation of a sensory thiol but by the oxidation of a prosthetic iron atom, in a Fenton-type reactionan event that seems likely to be H 2 O 2 -specific ( 2 O 2 defenses like AhpCF and catalase and the miniferritin Dps, but they do not usually include thioredoxins and glutaredoxins ( Streptomyces coelicolor and the Spx systems of Bacillus subtilis and Staphylococcus aureus have been most closely studied ( 2 O 2 is not an effective trigger for these regulons, and the natural inducers remain unknown

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[DOI] [PubMed] [Google Scholar] 32.Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, et al