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This synergy may result from GHK-Cu stimulating glycosaminoglycan production and promoting collagen synthesis, while HA may reduce collagen degradation by scavenging reactive oxygen species and inhibiting matrix metalloproteinases

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However, within infants born to women with diabetes who took second-line non-insulin ADMssulfonylureas, DPP-4 inhibitors, GLP-1 receptor agonists, or SGLT2 inhibitorsthe study did not find a greater risk of MCMs after periconceptional exposure compared with infants exposed to insulin