SLC7A11 is implicated in tumor development through its regulation of redox homeostasis, amino acid metabolism, modulation of immune function, and induction of programmed cell death, among other processes relevant to tumorigenesis
Two complementary lineagessystem Xc inhibitors and GPX4-directed agentsoffer improvements in potency, stability, or solubility, yet translation is constrained by on-target depletion of cystine and glutathione in normal tissues and by off-target perturbations, including mitochondrial channel engagement and p53 pathway modulation, which collectively narrow the therapeutic index
Some examples of autoimmune connective tissue diseases include: Polymyositis and dermatomyositis Rheumatoid arthritis (RA) Scleroderma Sjogren's syndrome Systemic lupus erythematosus (SLE or lupus) Vasculitis Mixed connective tissue disease (MCTD) Symptoms of connective tissue diseases can vary depending on the specific condition and the parts of the body affected
In addition, GPX4 has been shown to govern lipoxygenases activities in the AA metabolism ( 4 , 12-HETE, and 15-HETE) in the presence of GPX4 activator compound 102 ( Supplementary Figure S3B )
