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Schematic representation of the main pathophysiological mechanisms (lipotoxicity, oxidative stress, inflammation, and gut-liver axis) and therapies under evaluation directed at these processes, including THR- agonists, FGF-21 analogs, pan-PPAR modulators, GLP-1 RAs, and GLP-1/GIP combinations, in addition to conventional treatments such as SGLT-2 inhibitors, metformin, statins, and vitamin E

The third arm is what sets retatrutide apart from every approved incretin drug: glucagon-receptor agonism

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