Clin Exp Pharmacol Physiol 29:10181023 OShea RD, Lau CL, Farso MC, Diwakarla S, Zagami CJ, Svendsen BB, Feeney SJ, Callaway JK, Jones NM, Pow DV, Danbolt NC, Jarrott B, Beart PM (2006) Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: evidence for delayed up-regulation and redistribution of GLT-1
In recent years, with the increasing resolution of the ASCT2 3D structure, cysteine residue C467 is an important part of the composition of the ASCT2 substrate binding site, and residue C467 plays a key role in recognizing and binding glutamine [176]
En esos casos, el ajuste de la dosis permite realizar aumentos graduales y dar tiempo a que el medicamento se acumule en tu sistema y se reduzca el riesgo de efectos secundarios durante el perodo de ajuste
Furthermore, the integration of proteomic, transcriptomic, and metabolomic data enables the reconstruction of multilayered regulatory networks that underlie mitochondrial and metabolic functions [170, 171]