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However, most of the studies have reported observational results and phenotype changes rather than the mechanisms of action related to the crucial pathogenesis

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In some instances, upon administration of a controlled release auris formulation or composition described herein, drug concentrations relative to the binding constants of two receptors, such as, by way of example only, mineralcorticoid receptor (MR) and glucocorticoid receptor (GR), are relevant in determining the C min or the biologically most meaningful PK profile

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